The computerized adaptive testing (CAT) version of the Neuro-quality of life (Neuro-QOL) for patients with multiple sclerosis (MS) shows many of the expected associations with clinical and patient-reported outcome measures, a recent study found. Subjects (n=364) enrolled in SysteMS completed the CAT version of the Neuro-QOL and the 36-Item Short Form Survey (SF-36) within 4 weeks of a clinical exam that included the Multiple Sclerosis Functional Composite-4 (MSFC-4). The correlations between the Neuro-QOL domains, MSFC-4 subscores, and the SF-36 scores were calculated. The changes over time in the Neuro-QOL and other measures were also examined. Researchers found:

• The lower extremity functioning score of the Neuro-QOL showed the highest correlations with MSFC-4 components including Timed 25-Foot Walk, 9-Hole Peg Test, and cognitive score.
• The expected domains of the Neuro-QOL showed high correlations with the SF-36 subscores, and some Neuro-QOL domains were associated with many SF-36 subscores.
• There was limited longitudinal change on the Neuro-QOL domains over 12 months, and the change was not associated with change on other measures.