Several factors associated with worsening in timed 25-foot walk (T25FW) scores and other clinical indicators may be used to predict clinically significant change in patients with multiple sclerosis, according to an analysis of 1,544 patients.
Investigators reviewed patients who experienced a 20% or greater worsening in T25FW, and found the following factors related to disease progression:
• lower baseline Multiple Sclerosis Performance Scales (MSPS) scores
• sex, baseline T25FW, and time since diagnosis
• Patient Health Questionaire-9 (PHQ9) scores
The disease course time to worsening was significantly shorter for secondary progressive compared to relapsing-remitting disease.
Citation: Miller DM, Thompson NR, Cohen JA, et al. Factors associated with clinically significant increased walking time in multiple sclerosis: results of a survival analysis of short-term follow-up data from a clinical database. Mult Scler. 2015;21(4):457-465. doi: 10.1177/1352458514544536.