APBD is a genetic disorder that is frequently misdiagnosed as ALS, MS, and other neurological conditions. Early symptoms usually include bladder dysfunction and gait problems. These symptoms begin in middle age and eventually progress to complete loss of bladder control, inability to walk, and, in some cases, cognitive decline. A study reported in the July 2015 issue of Neurology showed an average of 6.8 years from presentation to diagnosis. All 30 patients in the study were initially misdiagnosed. More information.