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Genetic variants in nudix hydrolase linked to thiopurine myelosuppression

Publish date:: March 5, 2020

Key clinical point: A growing body of evidence supports genotyping the thiopurine-metabolizing enzyme nudix hydrolase, in addition to thiopurine methyltransferase, before starting someone on a thiopurine.

Major finding: Carriage of any of three coding NUDT15 variants greatly increased the risk of thiopurine-induced myelosuppression (odds ratio, 27.3; 95% confidence interval, 9.3-116.7)

Study details: A genetic analysis of NUDT15 in inflammatory bowel disease patients

Disclosures: The work was funded by the National Institutes of Health, Crohn’s & Colitis UK, the Wellcome Trust, and others. Dr. Walker and other investigators reported numerous industry ties.

Citation:

Walker GJ et al. JAMA. 2019 Feb 26;321(8):773-85.

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