Dr. Coutré is associate professor, division of hematology, and director of the hematology clinic at Stanford (Calif.) University. He had no disclosures.
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Could transplants account for the increase?
While interesting, this report provides little insight into possible reasons for an observed increase in treatment-associated acute myeloid leukemia. As the authors point out, t-AML has declined in patients treated for ovarian cancer, likely due to a change in the standard chemotherapy used. For non-Hodgkin’s lymphoma, one would like to know if there has been a similar change in treatment, in the opposite direction, that accounts for an increase in t-AML. Is there a greater use of transplant, which is known to be associated with t-AML? Have these patients been treated more intensively with alkylator-based regimens?
Dr. Steven Coutré is associate professor, division of hematology, and director of the hematology clinic at Stanford (Calif.) University. He had no disclosures.
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