In those who fail therapy, it might be useful to increase prednisone to 60 mg/day and azathioprine to 150 mg/day. If there is still no response, it is worth trying mycophenolate mofetil or a calcineurin inhibitor such as tacrolimus, although these have only been assessed in small pilot studies and haven’t proved very successful. Transplant is also an option that generally works well for autoimmune hepatitis in patients who don’t respond to medical therapy and can be considered, particularly in young patients with otherwise good health, Dr. Luxon said.
Dr. Luxon had no relevant disclosures to report.