Translational Research
Conference Coverage
ASH: Gene therapy restores immune function to older children with SCID-X1
The first two patients treated had enhanced expression of B, T, and NK cells, with the cells continuing to show improvements.
Conference Coverage
ASH: Gene therapy reduces transfusion needs in beta-thalassemia major
Lentiviral-based gene therapy can lead to transfusion independence in some patients with beta-thalassemia major.
News
Imetelstat elicits response in myelofibrosis, thrombocythemia
Key clinical point: The telomerase inhibitor imetelstat showed promise in separate preliminary studies for treatment of myelofibrosis and...
News
CLL patients achieve remission with CAR-modified T-cells
Key clinical point: CAR-modified T cell therapy lacks the toxicities and limitations of allogeneic stem cell transplantation and may be an...
Conference Coverage
ABT-199 rebounds in advanced CLL after tackling tumor lysis syndrome
Major finding: The overall response rate was 77% with ABT-199 monotherapy and 84% with the addition of rituximab in relapsed or refractory CLL....
News
Cutaneous erythema predicted low-dose alemtuzumab response in leukemic cutaneous T-cell lymphoma
Major finding: Of 17 patients who presented with diffuse cutaneous erythema without superimposed plaques or tumors, 13 fully remitted on low-dose...
Conference Coverage
No survival benefit for routine surveillance scans in classical Hodgkin disease
Major finding: The ratio of scans to detected relapses was 18 for the clinical surveillance group and 124 for the routine scan group.
News
More Extensive Gene Profiling Urged in AML, MDS
Major Finding: In one study 97.3% of samples from patients with AML had mutations in 18 genes.