Pediatrics
News
Treatment for pediatric low-grade glioma is associated with poor cognitive and socioeconomic outcomes
The risk for poor outcomes is greater when treatment includes radiotherapy, compared with surgery alone.
From the Journals
‘Robust antitumor immune responses’ observed in pediatric ALL
Tumor-associated CD8+ T cells responded to 86% of neoantigens tested and recognized 68% of neoepitopes tested in samples from pediatric ALL...
Guidelines
NCCN publishes pediatric ALL guidelines
While treatment for ALL often includes long-term chemotherapy regimens, various types of immunotherapy and targeted therapy are also summarized in...
Conference Coverage
Combo produces ‘best response rate’ after first relapse in kids with AML
CHICAGO – CPX-351 followed by fludarabine, cytarabine, and filgrastim produced an overall response rate of 81%.
Conference Coverage
Trial matches pediatric cancer patients to targeted therapies
Nearly a quarter of the patients screened as part of the National Cancer Institute–Children’s Oncology Group Pediatric MATCH trial have been...
Conference Coverage
Entrectinib exhibits activity in children with solid tumors
Entrectinib produced responses in patients who had fusions or mutations in target genes.
From the Journals
Low-dose FVIII prophylaxis reduced bleeding in hemophilia A
Low-dose prophylaxis with factor VIII outperformed on-demand treatment in children with severe hemophilia A. The findings have implications for...
Conference Coverage
NGS comparable to FC for minimal residual disease assessment
NEW ORLEANS – NGS of peripheral blood proved at least as effective as flow cytometry for assessing MRD in children and young adults with B-ALL who...
Conference Coverage
QOL concerns prompt second-line therapy in children with ITP
NEW ORLEANS – Quality of life was the most common reason for starting second-line therapy in a cohort of children with immune thrombocytopenia.
Conference Coverage
Master trial seeks to aid drug development for pediatric AML
NEW ORLEANS – “What we see in childhood AML is a lot different than what we see in adult AML, and this challenges the paradigm that we have...
Conference Coverage
Next-generation sequencing test detects pathogens with high sensitivity
NEW ORLEANS – The test detected pathogens with 92% sensitivity, which was more sensitive than conventional testing methods.