Gynecologic Cancer
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Palliative care consultations improve outcomes, but referrals lag
Major finding: Palliative care consultation was associated with 12%-57% reductions in mean pain, fatigue, anxiety, depression, nausea, drowsiness...
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Launch of rare-cancer trial spurs many more
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Vaginal cuff brachytherapy plus chemotherapy no better than pelvic radiation in early endometrial cancer
Major finding: Survival: 93% and 92%; recurrence-free survival: 82% and 84% with pelvic radiation therapy vs. vaginal cuff brachytherapy followed...
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Biomarkers identified that predict residual disease in ovarian cancer
Major finding: Odds ratio for residual disease in patients with high FABP4 levels: 5.5.Data source: An analysis of information from 680 patients...
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Ascites predicts bevacizumab benefit in advanced ovarian cancer
Major finding: Ascitic patients treated with bevacizumab had significantly better overall and progression-free survival (hazard ratios, 0.82 and 0...
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Sentinel lymph node mapping showed high diagnostic accuracy in endometrial cancer
Major finding: Sentinel lymph nodes identified metastatic disease in 11 of 11 node-positive patients, for a sensitivity and a negative predictive...
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Ability to perform daily activities did not predict chemotherapy tolerability in elderly women
Major finding: Instrumental Activities of Daily Living scores were not significantly associated with the ability to complete four chemotherapy...
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Bariatric surgery reduces uterine cancer risk
Major finding: Bariatric surgery was associated with a 70% reduction in risk of uterine cancer.Data source: A retrospective cohort study involving...
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Oophorectomy did not eliminate uterine cancer risk in BRCA1 mutation carriers
Major finding: Women with a BRCA1 mutation who underwent risk-reducing salpingo-oophorectomy without hysterectomy had a 2.1% 10-year risk of...
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The push for smaller, smarter cancer trials
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Whole-genome sequencing not ready for prime time
Major finding: For each participant, whole-genome sequencing identified between 90 and 127 novel or rare genetic variations, and between 12 and 20...