GI Oncology
News
Neoadjuvant capecitabine equals infused 5-FU for rectal cancer
Major finding: Capecitabine and infused 5-FU yielded statistically indistinguishable rates of locoregional control approaching 90%.
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Expanded genetic testing better predicts panitumumab plus chemo response
Major finding: Patients with the extended set of RAS mutations derived little to no benefit when panitumumab was added to FOLFIRI chemotherapy: 15...
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CT, CEA alone or combined better than nothing to detect colon cancer recurrence
Major finding: Colon cancer recurrences were detected (and operated upon) in 6.7% of the CEA-only group, 8% of the CT-only group, and 6.6% of the...
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Canadian agency reports rare, severe skin reactions to cancer drug
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Sequester continuing to hit cancer research hard
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Optimized colonoscopy slashes colorectal cancer incidence, deaths
Major finding: Optimized colonoscopy screening reduced the incidence of colorectal cancer by 83% and the incidence of colorectal cancer death by...
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Screening yields long-term reduction in CRC mortality
Major finding: After 30 years, participants who had been screened annually and biennially had respective 32% and 22% reductions in colorectal...
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Widespread screening linked to fewer colorectal cancer deaths
Major finding: A history of at least one endoscopic exam explained 73% of the decrease in colorectal cancer mortality in men and 82% of the...
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TP53 status signals neoadjuvant cetuximab benefit in rectal cancer
Major finding: In TP53 wildtype patients, neoadjuvant cetuximab improved 5-year progression-free survival by 24.3% (hazard ratio, 0.23; P = .02)...
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HLA class I plays role in aspirin’s benefit in colon ca
Major finding: Low-dose aspirin cut the risk of death in half in colon cancer patients with tumors expressing HLA class I.Data source: Microarray...
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Sulfasalazine may make radiation-induced diarrhea worse
Major finding: In all, 29% of patients who received sulfasalazine prophylactically had grade 3 or 4 diarrhea, compared with 11% of patients who...