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BMI and Tumor Phenotype in CRC

High BMI reduces benefit of MSI-high tumors

Publish date:: June 9, 2015

High pre-diagnosis BMI was consistently associated with increased mortality across participant subgroups, including strata of tumor molecular phenotype, according to a study of 5,615 men and women diagnosed with invasive colorectal cancer. Researchers found:

• High pre-diagnosis body mass index (BMI) was associated with increased risk of all-causes mortality for both sexes, with similar associations when stratified by sex, colon vs rectum, microsatellite instability (MSI) status, and BRAF-mutation status.

• Using MS-stable/MSI-low and normal BMI as a reference group, risk of death was 1.32 times higher for MS-stable/MSI-low and obese BMI, not statistically significantly for MSI-high and normal BMI, and about the same for MSI-high and normal BMI.

Citation: Campbell PT, Newton CC, Newcomb PA, et al. Association between body mass index and mortality for colorectal cancer survivors: overall and by tumor molecular phenotype. [Published online ahead of print May 18, 2015]. Cancer Epidemiol Biomarkers Prev. doi:10.1158/1055-9965.EPI-15-0094.

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