Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

T cell infusion effective in PML

Muftuoglu M et al. N Engl J Med. 2018 Oct 11;379:1443-51

Publish date:: October 12, 2018

Key clinical point: Infusion of allogeneic BK virus-specific T cells may be an effective treatment for patients with PML.

Major finding: Two of three patients cleared JC virus from cerebrospinal fluid after infusion.

Study details: A case series involving three patients with PML.

Disclosures: The study was funded by the MD Anderson Cancer Center Moon Shots Program and the National Institutes of Health.

Read the article.

Citation:

Muftuoglu M et al. N Engl J Med. 2018 Oct 11;379:1443-51

This Week's Must Reads

Younger adults present with more advanced esophageal adenocarcinoma,

PDAC: Tumor reduction after neoadjuvant therapy may predict postsurgical survival,

Mortality risks rise with age, infections, but not inhibitor status in persons with non-severe hemophilia A,

‘Impressive’ local control with MRI-guided brachytherapy in cervical cancer,

U.S. mothers underestimate role breastfeeding plays in curbing breast cancer,

Must Reads in AML

Beat AML: Precision medicine strategy feasible, superior to SOC for AML,

Survey quantifies COVID-19’s impact on oncology,

Combo drug improves survival in older patients with high-risk/secondary AML,

Venetoclax plus LDAC tops LDAC alone in AML,

Azacitidine plus enasidenib improves response, but not survival, in mIDH2 AML,