AML
Conference Coverage
EHA: High-risk APL curable with chemo-free combo
Key clinical point: Arsenic trioxide plus all-trans retinoic acid is at least equivalent to all-trans retinoic acid and idarubicin in terms of...
News
Clonal hematopoiesis explored in aplastic anemia
Key clinical point: Clonal hematopoiesis was detected in 47% of 439 patients with aplastic anemia, and some of the mutations were related to...
Conference Coverage
Jury still out on combo for elderly AML
Photo courtesy of NIH VIENNA—A 2-drug combination can produce complete responses (CRs) in elderly patients with newly diagnosed acute myeloid...
Conference Coverage
Drug may be ‘important treatment option’ for AML
Photo courtesy of ASH VIENNA—Adding the anticancer quinolone derivative vosaroxin to treatment with cytarabine can improve outcomes for some...
News
Avocado-derived compound could treat AML
lab, surrounded by avocados Photo by Light Imaging/ University of Waterloo A compound derived from avocados could be effective in treating acute...
News
IDH1 inhibitor gets orphan designation for AML
The US Food and Drug Administration (FDA) has granted orphan designation for AG-120 to treat patients with acute myeloid leukemia (AML) who harbor...
News
Pathway may play key role in FLT3-ITD AML
Results of preclinical research suggest the Hedgehog signaling pathway works with FLT3-ITD mutations to accelerate the development of acute...
Conference Coverage
A better FLT3 inhibitor for AML?
© ASCO/Scott Morgan CHICAGO—A dual inhibitor of FLT3 and Axl may produce more durable responses than other FLT3 inhibitors and improve survival...
News
CD8 cell dose predicts outcomes in allogeneic stem cell transplantation with reduced-intensity conditioning
Key clinical point: High CD8 cell dose in peripheral blood stem cell grafts was associated with reduced risk of relapse and increased survival in...
Conference Coverage
LSC phenotypes correlate with prognosis in AML
© ASCO/Rodney White CHICAGO—Researchers say they have identified 3 leukemia stem cell (LSC) phenotypes that are correlated with cytogenetic/...
News
DART molecule proves active against AML
Photo by Sakurai Midori An artificial antibody that redirects T cells to target cancer cells shows promise for treating acute myeloid leukemia (...