Secondary endpoints included the combined endpoint with the target rate of CSBM achieved in at least 9 of the first 12 weeks, 18% on the active drug and 5% on placebo, and in at least 13 of the 26 weeks on treatment, 36% on tenapanor and 24% on placebo. After 26 weeks on treatment, 55% of patients on tenapanor rated themselves as quite satisfied or very satisfied with their treatment, compared with 33% of the placebo-control patients.
T3MPO-2 was funded by Ardelyx, the company developing tenapanor. Dr. Chey has been a consultant to and has received research funding from Ardelyx and from several other companies. A coauthor on the study was an Ardelyx employee.
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