Conclusion
Not all clinical guidelines are created with equal rigor. Clinicians should examine guidelines closely and consider whether or not they follow the Institute of Medicine’s standards for trustworthy clinical guidelines: Is the focus on transparency? Is a rigorous conflict of interest system in place that eliminates major sources of financial and intellectual conflict? Was an unconflicted GRADE-trained methodologist involved in ensuring that a systematic review process is followed and the method of rating the quality of evidence and strength of recommendation follows published principles? Are the recommendations clear and actionable?3 AGA Institute guidelines are developed with the goal of striking a balance between presenting the highest ideals of evidence-based medicine while remaining responsive to the needs of everyday practitioners dealing with real patients in real clinical settings.
Ms. Siedler is the director of clinical practice at the AGA Institute national office in Bethesda, Md.; Dr. Falck-Ytter is a professor of medicine at Case-Western Reserve University, Cleveland, chair of the AGA Institute Clinical Guidelines Committee, and chief of the division of gastroenterology at the Louis Stokes VA Medical Center in Cleveland. The authors disclose no conflicts of interest.
References
1. Hanson B., Siedler M., Falck-Ytter Y., Sultan S. Introducing the rapid review: How the AGA is working to get trustworthy clinical guidelines to practitioners in less time. AGA Perspectives. 2017; in press.
2. Siedler M., Allen J., Falck-Ytter Y., Weinberg D. AGA clinical practice guidelines: Robust, evidence-based tools for guiding clinical care decisions. Gastroenterology. 2015;149:493-5.
3. Institute of Medicine: Standards for developing trustworthy clinical practice guidelines. Available at http://www.nationalacademies.org/hmd/Reports/2011/Clinical-Practice-Guidelines-We-Can-Trust/Standards.aspx. Last accessed May 2017.Process for the selection of new guideline topics
