In this special supplement to Federal Practitioner, Dr. Binu John of the University of Miami discusses the challenges and treatment options for Hepatocellular Carcinoma (HCC), a common type of liver cancer, with a focus on patients with Child-Pugh B cirrhosis. It highlights the increasing incidence of liver cancer, especially in the context of cirrhosis caused by various factors, and the significance of early diagnosis and curative treatment in improving survival rates.