Dr. Richey, Dr. Jovic, and Dr. Rakhman are clinical pharmacy specialists, and Dr. Waters is an infectious disease pharmacist, all at the Jesse Brown VAMC in Chicago, Illinois.
Although this was a very small retrospective analysis, to the authors knowledge this is the first clinical study supporting the in vitro theory that amoxicillin (500 mg every 8 hours) may overcome the MIC of resistant isolates due to achievement of higher urinary concentrations. Because this was a small retrospective analysis, more prospective evidence is needed to confirm these results.
Acknowledgements Heather Kim, biostatistician, University of Illinois at Chicago. CCTS Support: UL1RR029879.
Author disclosures The authors report no actual or potential conflicts of interest with regard to this article.
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