Applied Evidence

Intra-Articular Injections of the Knee: A Step-by-Step Guide

Author and Disclosure Information

 

References

Although some training is required, intra-articular injections are no longer considered an orthopedic subspecialty procedure, and there are a number of benefits to incorporating these injections into your practice. Many patients appreciate their primary care clinician making available services that traditionally required a referral to a specialist. Patients also avoid treatment delays.

Here is a step-by-step guide to familiarize you with the technique.

STEP 1: Selecting an injection approach

Common approaches for injecting the knee include the following1 :

  • Anterolateral (flexed knee)
  • Anteromedial (flexed knee)
  • Superolateral/lateral suprapatellar (straight knee)
  • Superomedial/medial suprapatellar (straight knee)
  • Lateral mid-patellar
  • Medial mid-patellar.

One study found that the accuracy of the first attempt at needle placement was highest for lateral mid-patellar (93%) compared with anteromedial (75%) and anterolateral (71%) approaches (superolateral approach not done).

STEP 2: Identify and mark the injection site2

For superolateral approach:

  • Palpate superolateral and lateral edges of patella with patient supine and leg straight
  • Mark where lines intersect as in diagram.

If the patient cannot completely extend the knee, placement of a rolled towel to support the knee will help provide the patient comfort and minimize muscle spasm, improving the likelihood of a successful and comfortable injection.

STEP 3: Preparing the injection site2

  • Aseptic technique
  • – Swab area 3 times with a povidone iodine preparation (Beta-dine) and let dry.
  • Local anesthetic options
  • – Lidocaine
  • – Vapocoolant spray

STEP 4: Aspiration (skip to Step 5 if no effusion is present)

If effusion is present, aspiration of the effusion can relieve patient discomfort, be of diagnostic benefit, and avoid dilution of a visco-supplement to be injected.2

  • Insert 1 ½” 18-gauge needle for aspiration3
  • If needle is accurately placed, the syringe should fill with fluid1
  • Compression of the opposite side of the joint or the patella may aid in arthrocentesis.3

STEP 5: Injection

If aspiration was required, the same needle can be used for aspiration and injection by changing the syringe.

  • Insert needle (1 ½”, 21-gauge for corticosteroids; 1 ½”, 20- or 22-gauge for viscosupplementation) ¾” to 1 ¼” for injection
  • Remove needle, wipe off povidone iodine solution, and apply bandage.

Post-injection care: Setting patient expectations and managing adverse effects

  • Patient should avoid strenuous activity for 1 to 2 days after injection and apply ice to injection site
  • Mild pain or swelling at the injection site can occur, but is rare
  • – If mild pain or swelling occurs, recommend ice, nonsteroidal anti-inflammatory drug (NSAID), rest, and elevation
  • – If significant pain or swelling occurs:
  • Joint aspiration
  • Send aspirate to lab to rule out joint infection
  • Crystal analysis
  • May provide intra-articular corticosteroid to decrease pain and inflammation after viscosupplementation if infection has been excluded.

Recommended Reading

Hyaluronic Acid Confers Long-Standing Pain Relief in Knee OA
MDedge Family Medicine
Oral Calcitonin Found Beneficial in Knee Osteoarthritis
MDedge Family Medicine
'No Pain, No Gain' Applies to Strength Training
MDedge Family Medicine
Insoles Ease Knee Pain Best in the Flat Footed
MDedge Family Medicine
In Knee Osteoarthritis, Pain Is Where the Pathology Is
MDedge Family Medicine
Cardiac Contraindications Don't Stop Triptan Prescriptions for Migraine
MDedge Family Medicine
RA Patients Have Made Treat-to-Target Personal
MDedge Family Medicine
Studies Compare Surgical Options for Trigeminal Neuralgia
MDedge Family Medicine
Transdermal Opioid Eases Low Back Pain
MDedge Family Medicine
Arthritis pain? These supplements provide little relief
MDedge Family Medicine