There were no grade 3 or 4 toxicities. Mild to moderate diarrhea was reported in 1.9% of patients who took one capsule daily and in 13.5% of those taking three capsules daily. There were no significant changes in testosterone from the baseline value of more than 1.5 ng/mL.
Ultimately, the decision to use pomegranate extract or juice is a matter of discussion between physician and patient, Dr. Carducci said in the interview.
"I think with two consistent data sets showing slowing PSA doubling time, it would be reasonable for a patient to consider and understand what he’s getting himself into," he said. "It’s possible that patients with slower growing disease may have the greater benefit."
The meeting was sponsored by the American Society for Clinical Oncology, the American Society for Radiation Oncology, and the Society of Urologic Oncology. Dr. Carducci is an unpaid consultant for and has received research funding from the study sponsor, POM Wonderful. Dr. Morris disclosed relationships with nine companies.