The updated dosing regimen for pediatric patients who have that rate of creatinine clearance but are on intermittent hemodialysis varies according to age. From birth through 30 days, infants should receive 1 mg/kg peramivir on day 1, followed by 1 mg/kg 2 hours after each hemodialysis session on hemodialysis days only. Following the same instructions, the dose increases to 1.3 mg/kg for infants 31–90 days old, 1.6 mg/kg for infants aged 91–180 days, 1.9 mg/kg for children 181 days to 5 years of age, and then back to 1.6 mg/kg for children aged 6–17 years.
Peramivir dosing for children who have a creatinine clearance of less than 10 mL/minute per 1.73 m
The recommendations are available at
www.flu.gov/individualfamily/prevention/medicine/antiviralsrecommend.html