Prazosin provides significant relief in small study of combat veterans
A 2013 RCT evaluated the effect of prazosin on nightmares in 67 soldiers with combat PTSD.2 All patients met criteria for PTSD as outlined in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. Men received doses titrated to a mean of 4 mg in the morning and 15.6 mg at bedtime; women received a mean of 1.7 mg in the morning and 7 mg at bedtime.
After 15 weeks, the CAPS-B2 score decreased by 3.1 for prazosin compared with 1.2 for placebo (P<.05).