Osteoporosis
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Loss of BMD linked to knee OA progression
Major finding: BMD loss of 0.1 g/cm2 was associated with a 1.25% per year loss of cartilage volume.Data source: An observational cohort study of...
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USPSTF recommends against postmenopausal vitamin D/calcium supplementation
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Vitamin D lowered aldosterone in heart failure
Major Finding: Six months of oral vitamin D3 at 50,000 IU/wk resulted in a 37% reduction in serum aldosterone and a 41% decrease in baseline...
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Metabolic bone disease markers poor in CKD patients with HF
Major Finding: The adjusted mean for serum calcium was significantly lower in patients with heart failure at each CKD stage, while the adjusted...
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Bone Risks of Older Antiepileptics Sometimes Unaddressed
Major Finding: Uninsured women and those on Medicaid were about half as likely to be warned of the bone health impacts of older antiepileptic...
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Osteoporosis, Vertebral Fractures May Flag Heart Risk in RA
Major Finding: Of 603 patients from a convenience sample of adults who met 1987 ACR criteria for RA classification, 230 had at least one...
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Vitamin D Assays Flawed, but Improving
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New Assay Simultaneously Measures Vitamin D Metabolites
Major Finding: The limit of detection in the assay for 24,25(OH)2D3 was 0.08 ng/mL; the limit for 24,25(OH)2D2 was 0.5 ng/mL.Data Source: Data are...
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Odanacatib Adds Bone in Alendronate-Pretreated Osteoporosis
Major Finding: The change from baseline in femoral neck bone mineral density at 2 years was +1.73% with odanacatib vs. –0.94% for placebo (P less...
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Zoledronic acid cuts vertebral fracture risk 67% in men with osteoporosis
Major Finding: Of the men receiving zoledronic acid, 1.6% developed new vertebral fractures during 2-year follow-up, compared with 4.9% of those...
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Calcium Protective Against Hyperparathyroidism
Major Finding: Women in the highest quintile of dietary calcium intake had a relative risk for developing hyperparathyroidism of 0.61, compared...