Calcipotriene–Betamethasone Dipropionate Topical Suspension in the Management of Psoriasis: A Status Report on Available Data With an Overview of Practical Clinical Application
Cutis. 2014 September;94(3):127-134
James Q. Del Rosso, DO
From the Touro University College of Osteopathic Medicine, Henderson, Nevada, and Las Vegas Skin and Cancer Clinics/West Dermatology Group, Las Vegas and Henderson.
Dr. Del Rosso is an advisory board member, consultant, and speaker for Allergan, Inc; Bayer Health Care Pharmaceuticals; Galderma Laboratories, LP; LEO Pharma; Promius Pharma; PuraCap Pharmaceutical; Ranbaxy Laboratories Limited; Taro Pharmaceuticals USA, Inc; and Valeant Pharmaceuticals International, Inc. He also is a consultant for Aqua Pharmaceuticals, and is a researcher for Allergan, Inc; Bayer Health Care Pharmaceuticals; Galderma Laboratories, LP; LEO Pharma; and Valeant Pharmaceuticals International, Inc.
What practical recommendations can be made regarding the use of C/Bd-TS for PP?
Calcipotriene 0.005%–Bd 0.064% topical suspension applied once daily provides a formulation that allows for treatment of PP involving both the scalp and body using a single product, which provides an element of convenience and is likely to enhance compliance and reduce costs compared with the use of 2 separate products. The efficacy and safety of C/Bd-TS has been well established in several studies,16-23,37 including a 52-week trial in patients with scalp psoriasis.36 The combination of calcipotriene and Bd appears to favorably address the pathophysiologic pathways involved in psoriasis.29,30 Calcipotriene 0.005%–Bd 0.064% topical suspension is a rational option for the treatment of PP in patients with localized disease or in patients treated systemically or with phototherapy for more extensive disease who exhibit persistence or recurrence of scattered areas of PP.6-9,14,15 Appropriate use of C/Bd-TS is likely to achieve favorable efficacy with a low risk of tolerability reactions and a very low risk of major adverse drug reactions.16-23,36-38