Serum Interferon-γ Is a Psoriasis Severity and Prognostic Marker

The aim of this study was to measure serum interferon-γ (IFN-γ) levels in participants with different types and severities of psoriasis. The study was conducted on 21 participants with psoriasis. Participants were divided into 3 groups according to disease severity: erythrodermic, severe plaque, and mild to moderate plaque psoriasis. Fifteen participants received different treatment modalities for 16 weeks and were followed for an additional 12 weeks. The enzyme-linked immunosorbent assay technique was used to measure serum IFN-g levels in participants before treatment and compared with matched controls and participants receiving treatment. Significant differences were detected between participants and controls in mean serum IFN-g levels before treatment (P<.05 there was a positive correlation between serum ifn-g levels and psoriasis area severity index scores clinical type of with the highest in erythrodermic group lowest mild to moderate plaque group. irrespective treatment participants who showed improvement disease condition significant decrease pasi also had class="article_abstract_nonital">P<.05 moreover participants with serum ifn-g levels that did not dramatically decrease had a shorter remission period compared those who showed significant in levels. the substantial elevation and variation according to disease severity suggest has role determining therapy evaluation which encourages further research on anti biologic treatment of psoriasis.>