Article

Basic Fibroblast Growth Factor Treatment for Skin Ulcerations in Scleroderma

Cutis. 2005 December;76(6):373-376
By
Yamanaka K-I
Inaba T
Nomura E
Hurwitz D
Jones DA
Hakamada A
Isoda K
Kupper TS
Mizutani H
Author and Disclosure Information

We report the use of topical application of recombinant human basic fibroblast growth factor (rhbFGF) to successfully treat therapy-resistant, chronic leg ulcers in scleroderma. Endothelial cell FGF receptors are directly stimulated by bFGF; also, bFGF promotes the regeneration of capillary-rich granulation tissue. We conclude that topical bFGF may be a powerful new pharmacologic tool for treating severe skin ulcers.
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