Frictional asymptomatic darkening of the extensor surfaces (FADES) is commonly seen in our practice but has not been well characterized in the dermatologic literature. We can find no mention of frictional dermatitis or hyperkeratosis of the elbows and knees in any of the major textbooks of dermatology.1-6 Young to middle-aged adults present with asymptomatic "dirty" brown pigmentation over the extensor surfaces of their elbows and knees, which the patients find cosmetically objectionable. The lesions are generally uniform and bilateral, with little evidence of scaling. A positive family history and a history of frictional stress to the involved areas can be elicited in some cases. Patients deny any symptoms of pain or pruritus, as well as exposure to contact allergens or a personal or family history of psoriasis vulgaris. We collected data from 9 patients diagnosed with FADES, including detailed histories, biopsy results, and treatment outcomes. The cases of 4 representative patients are discussed.
Case Reports
Patient 1—A 47-year-old white woman presented with brownish discoloration of her knees and elbows of 5 years' duration. The left knee and both elbows showed darkening. She denied any pain, pruritus, history of trauma, family history, or contact allergen exposure. The patient reported kneeling on her left knee when working around the house. She was unable to kneel on her right knee because of pain associated with osteoarthritis. There was no history of diabetes mellitus or obesity. Results of a physical examination revealed a 3-cm area of brownish discoloration along the extensor surface of her left knee without any erythema or scaling (Figure 1). The skin over the right knee appeared normal. Similar but milder changes were noted on the extensor surfaces of her elbows bilaterally. No evidence of the velvety hyperpigmentation of acanthosis nigricans was present in flexural areas. Treatment with lactic acid 12% cream twice a day for 3 months led to slow steady improvement, which was quite satisfying to the patient, but the dark coloration was not totally eliminated.
Patient 2—A 58-year-old white man presented with "dirty" brown discoloration of his elbows bilaterally of 40 years' duration. He denied any pain or pruritus. No precipitating, exacerbating, or relieving factors were elicited. His medical history was significant for hypertension and arthritis. There was no history of diabetes mellitus or obesity. Family history was significant for the same condition in his mother and daughter. Results of a physical examination revealed a 4- to 5-cm macular area of brown discoloration along the extensor surfaces of each elbow without any erythema or scaling (Figure 2). No evidence of acanthosis nigricans was present in flexural areas. Results of a 4-mm punch biopsy on his left elbow revealed benign papillomatosis with acanthosis, hyperkeratosis, and no significant inflammation (Figure 3). Treatment was initiated with urea 40% cream twice a day for 3 to 4 months with gradual improvement of the discoloration leading to overall mild to moderate improvement.
Patient 3—A 32-year-old white woman presented with "dirty" brown discoloration of her elbows and knees of 7 years' duration without associated pain or pruritus. She noted that the area on her knees appeared darker after several days of scrubbing the floors on her knees. Family history was positive for similar lesions on her father's elbows. There was no history of diabetes mellitus. Unsuccessful treatments included over-the-counter vitamin E lotion. Results of a physical examination revealed hyperpigmentation and lichenification with very mild scaling on the extensor surfaces of her knees (Figure 4) and elbows bilaterally. The changes were more pronounced on her knees than her elbows. There was no evidence of acanthosis nigricans in flexural areas. Results of a 4-mm punch biopsy on her right knee revealed benign papillomatosis with acanthosis and hyperkeratosis without any significant atypia, intradermal melanin deposition, or inflammation. She was treated with urea 40% cream once a day and instructed to advance to twice-a-day treatment if tolerated. No improvement was noted after one month of treatment, and she refused further treatment suggestions.
Patient 4—A 68-year-old white man presented with asymptomatic brown discoloration of his elbows and knees bilaterally of 20 years' duration. He denied any known precipitating factors but stated that he worked on his elbows and knees a lot when gardening. There was no history of diabetes mellitus or obesity. Unsuccessful treatments included intermittent use of over-the-counter Udderly SMOOth® Udder Cream for 3 to 4 years without any noticeable improvement. Family history was significant for similar lesions on his son's knees. Results of a physical examination revealed mildly hyperpigmented erythematous patches bilaterally on the extensor surfaces of his knees (Figure 5) and, to a lesser degree, on his elbows without any scaling. No evidence of acanthosis nigricans was present in flexural areas. Treatment was initiated with lactic acid 12% cream twice a day. After 3 years of daily use, the brown discoloration improved by 75% to 80%.
Comment To our knowledge, this is the first report in the United States of FADES. "Dirty" brown discoloration is noted over the extensor surfaces in areas prone to frictional stress. Pain and pruritus are uniformly absent. Biopsy results of these lesions reveal mild papillomatosis with acanthosis and hyperkeratosis, with minimal underlying inflammation (Figure 3). Melanin deposition in the dermis is not identified as is commonly seen in postinflammatory hyperpigmentation (PIH). Spongiosis typical of eczema and psoriasiform hyperplasia typical of psoriasis are not present. We chose to use the word darkening in the name rather than hyperpigmentationbecause the color change in this condition is a result of papillomatosis, acanthosis, and hyperkeratosis rather than excess melanin pigment. The pathology also led us to use keratolytic agents as treatment rather than hydroquinone-based fade creams. In most cases of FADES, treatment with lactic acid 12% or urea 40% cream over 3 to 6 months is at least partially effective (Table).