Erythromelalgia is a difficult diagnosis to make and often is a difficult disease for the patient to endure. Special care should be taken by the clinician to search for an underlying disorder when this diagnosis is made and during follow-up. Treatment is directed at the underlying cause, if discernible, and at the symptomatic relief of the patient. Prognosis is mixed; approximately the same number of individuals will improve, remain stable, or worsen, even with referral to a large tertiary care setting with multiple resources.1