Case Reports

Necrotizing Cellulitis With Multiple Abscesses on the Leg Caused by Serratia marcescens

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Conclusion

Although uncommon, an S marcescens skin infection may be suspected in cases of cellulitis in immunocompromised patients, especially when conventional antibiotics are not effective. Serratia marcescens naturally produces a cephalosporinase that confers resistance to amoxicillin and to amoxicillin associated with clavulanic acid. Broad-spectrum antibiotics such as third-generation cephalosporins, fluoroquinolones, or imipenem-cilastatin are indicated in cases of S marcescens skin infections, and surgery should be promptly considered if appropriate antibiotic therapy does not lead to rapid clinical improvement.

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