Applied Evidence
Clinical Inquiries
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Clinical Inquiries
Are inhalers with spacers better than nebulizers for children with asthma?
EVIDENCE-BASED ANSWER: Metered-dose inhalers with a spacer (MDI/S) are as good as, or better than, nebulizers for children with asthma. This is...
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Clinical Inquiries
Do antipyretics prolong febrile illness?
EVIDENCE-BASED ANSWER: Antipyretics appear to have minor and variable effects on the course of febrile illness. Aspirin and acetaminophen do not...
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Clinical Inquiries
Is folate supplementation indicated for patients with CAD?
EVIDENCE-BASED ANSWER: There is insufficient evidence to advocate the routine use of folate supplementation for the treatment of coronary artery...
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Clinical Inquiries
Are liver function tests required for patients taking isoniazid for latent TB?
EVIDENCE-BASED ANSWER: Routine liver function test monitoring is not required for all patients on isoniazid therapy for latent tuberculosis (TB)...
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Clinical Inquiries
Do ACE inhibitors prevent nephropathy in type 2 diabetes without proteinuria?
EVIDENCE-BASED ANSWER: Angiotensin-converting enzyme (ACE) inhibitors make a significant difference for patients with diabetes as a whole. If...
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Clinical Inquiries
How accurate is stress radionuclide imaging for diagnosis of CAD?
EVIDENCE-BASED ANSWER: Stress radionuclide testing is a moderately accurate test compared with coronary angiography for the diagnosis of coronary...
Commentary
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Commentary
Referral for small brain aneurysms
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Commentary
JFP: A new year full of opportunities
Original Research
Practice Alert
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Practice Alert
Preventing VTE in hospitalized patients
Photo Rounds
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Photo Rounds
Bald spots on a young girl
Q&A
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Q&A
Taper proton pump inhibitor to once daily for GERD
BACKGROUND: PPIs provide very effective, but expensive, therapy for GERD. Many people start on more than once-daily dosing.
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Q&A
Sertraline effective for children and adolescents with major depression
BACKGROUND: Few treatment options are available for children and adolescents with major depressive disorder due to a lack of efficacy data,...
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Q&A
Screening and intervention for excessive drinking produce small results
BACKGROUND: The World Health Organization has recommended screening for excessive alcohol consumption. However, the effectiveness of screening, as...
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Q&A
Azithromycin ineffective for secondary coronary heart disease prevention
BACKGROUND: Several studies have found an association between infection with C pneumoniae and atherogenesis. Unfortunately, results from smaller...
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Q&A
Influenza vaccine does not prevent acute otitis media in young children
BACKGROUND: Influenza vaccines have been shown to prevent acute otitis media in children aged <2 years; reductions of 30% to 44% have been...
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Q&A
Elevated D-dimer level predicts recurrent VTE
BACKGROUND: Management of patients with VTE after completion of anticoagulation remains controversial.