Applied Evidence
Clinical Inquiries
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Clinical Inquiries
Does tamoxifen prevent breast cancer?
EVIDENCE-BASED ANSWER: Tamoxifen prevents breast cancer in women older than 60 years and in younger women with equally high risk because of breast...
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Clinical Inquiries
What are the benefits of treating sleep apnea?
EVIDENCE-BASED ANSWER: There is little benefit to treating patients with sleep apnea who do not have daytime sleepiness. For patients with...
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Clinical Inquiries
What is the best approach to prevention and treatment of osteoporosis?
EVIDENCE-BASED ANSWER: Randomized controlled trials (RCTs) have demonstrated decreased vertebral and nonvertebral fracture rates in postmenopausal...
Commentary
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Commentary
It Takes a Balanced Health Care System to Get It Right
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Commentary
Costs of Writing Research Manuscripts
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Commentary
Treatment of Depression
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Commentary
The Mini Electronic Medical Record: A Low-Cost, Low-Risk Partial Solution
Electronic medical records (EMRs) offer many advantages. However, there are also risks involved with adopting a full commercial EMR. These include...
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Commentary
After Chanukah
Original Research
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Original Research
Why Some Cancer Patients Choose Complementary and Alternative Medicine Instead of Conventional Treatment
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Original Research
The Effect of Patient and Visit Characteristics on Diagnosis of Depression in Primary Care
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Original Research
Primary Care Physician Supply and Colorectal Cancer
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Original Research
Unlocking Specialists’ Attitudes Toward Primary Care Gatekeepers
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Original Research
Are Fluid-Based Cytologies Superior to the Conventional Papanicolaou Test? A Systematic Review
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Original Research
Diagnosing Influenza: The Value of Clinical Clues and Laboratory Tests
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Original Research
When Physicians and Patients Think Alike: Patient-Centered Beliefs and Their Impact on Satisfaction and Trust
Q&A
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Q&A
Is tolterodine (Detrol) or oxybutynin (Ditropan) the best for treatment of urge urinary incontinence?
Harvey MA, Baker K, Wells GA. Tolterodine versus oxybutynin in the treatment of urge urinary incontinence: a meta-analysis. Am J Obstet Gynecol...
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Q&A
Does episiotomy increase perineal laceration length in primiparous women?
Nager CW, Helliwell JP. Episiotomy increases perineal laceration length in primiparous women. Am J Obstet Gynecol 2001; 185:444-50.
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Q&A
In low to moderate risk patients with chest pain, is a 6-hour protocol able to accurately rule out acute myocardial infarction (AMI)?
Herren KR, Mackway-Jones K, Richards CR, Seneviratne CJ, France MW, Cotter L. Is it possible to exclude a diagnosis of myocardial damage within 6...
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Q&A
What is the diagnostic yield of a standardized sequential clinical evaluation of patients presenting to an emergency department with syncope?
Sarasin FP, Louis-Simonet M, Carballo D, et al. Prospective evaluation of patients with syncope: a population-based study. Am J Med 2001; 111:177-...
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Q&A
How common is peripheral arterial disease, and should primary care physicians be screening for it?
Hirsch AT, Criqui MH, Treat-Jacobson D, et al. Peripheral arterial disease detection, awareness, and treatment in primary care. JAMA 2001; 286:...
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Q&A
Do dietary restrictions reduce fecal occult blood testing adherence?
Pignone M, Campbell MK, Carr C, Phillipsa C. Meta-analysis of dietary restriction during fecal occult blood testing. Eff Clin Pract 2001; 4:150-56...
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Q&A
Does losartan (Cozaar) slow the progression of renal disease in patients with type 2 diabetes and nephropathy?
Brenner BM, Cooper ME, De Zeeuw D, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and...
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Q&A
Does long-term use of sibutramine (Meridia) result in continued weight loss in short-term responders?
BACKGROUND: Obesity, defined as a body mass index (BMI) equal to or greater than 30 kg/m2, is a common chronic disorder with a prevalence of 22.3...