Clinical Review

Time to Change How We Test for TB?

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References

CONCLUSION
Occupational health professionals are continuously evaluating how to improve surveillance programs and reduce HCWs’ time away from work. Within this context, four advantages IGRAs offer include
• Elimination of a two-step TST for new hires (which requires up to four separate visits)
• No false-positive results caused by previous BCG vaccination or exposure to most nontuberculous mycobacteria
• Significantly improved HCW compliance because screening requires only one visit
• Cost effectiveness.

From an occupational health perspective, these are significant advantages that support the use of IGRAs to screen HCW for TB.

REFERENCES
1. Wilson J. Five babies test positive for TB in Texas. CNN. September 30, 2014. www.cnn.com/2014/09/29/health/babies-test-positive-tb/index.html. Accessed November 12, 2014.

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3. CDC. Reported tuberculosis in the United States, 2013. www.cdc.gov/tb/statistics/reports/2013/pdf/report2013.pdf. Accessed October 23, 2014.

4. World Health Organization. Global tuberculosis report 2014. www.who.int/tb/publications/global_report/en/. Accessed November 12, 2014.

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7. Huebner RE, Schein MF, Bass JB Jr. The tuberculin skin test. Clin Infect Dis. 1993;17(6):968-975.

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10. Desem N, Jones SL. Development of a human gamma interferon enzyme immunoassay and comparison with tuberculin skin testing for detection of Mycobacterium tuberculosis infection. Clin Diagn Lab Immunol. 1998;5(4): 531-536.

11. FDA. QuantiFERON-TB - P010033. www.fda.gov/MedicalDevices/Products andMedicalProcedures/DeviceApprovalsandClearances/Recently-Approved Devices/ucm084025.htm. Accessed November 12, 2014.

12. QuantiFERON-TB Gold In-Tube Test [package insert]. www.quantiferon.com/irm/content/PI/QFT/2PK/US.pdf. Accessed November 12, 2014.

13. T-SPOT.TB [package insert]. Marlborough, MA. Oxford Immunotec, Inc. www.tspot.com/wp-content/uploads/2012/01/PI-TB-US-v4.pdf. Accessed November 12, 2014.

14. CDC. Fact sheet: infection control in health-care settings. www.cdc.gov/tb/publications/factsheets/prevention/ichcs.htm. Accessed November 12, 2014.

15. Jensen PA, Lambert LA, Iademarco MF, Ridzon R; CDC. Guidelines for preventing the transmission of Mycobacterium TB in health-care settings, 2005. MMWR Recomm Rep. 2005;54(RR-17):1-141.

16. Mazurek GH, Jereb J, Vernon A, et al; IGRA Expert Committee, CDC. Updated guidelines for using interferon γ release assays to detect Mycobacterium TB infection: United States, 2010. MMWR Recomm Rep. 2010;59(RR-5):1-25.

17. CDC. Latent tuberculosis infection: a guide for primary health care providers. www.cdc.gov/tb/publications/ltbi/diagnosis.htm. Accessed November 3, 2014.

18. Zwerling A, van den Hof S, Scholten J, et al. Interferon-γ release assays for TB screening of healthcare workers: a systematic review. Thorax. 2012;67(1): 62-70.

19. Eralp MN, Scholtes S, Martell G, et al. Screening of healthcare workers for TB: development and validation of a new health economic model to inform practice. BMJ Open. 2012;2:e000630.

20. FDA. FDA permits marketing of first US test labeled for simultaneous detection of tuberculosis bacteria and resistance to the antibiotic rifampin [press release]. July 25, 2013.

21. CDC. Availability of an assay for detecting Mycobacterium TB, including rifampin-resistant strains, and considerations for its use: United States, 2013 [published correction appears in MMWR Morb Mortal Wkly Rep. 2013;62(45):906]. MMWR Morb Mortal Wkly Rep. 2013;62(41):821-827.

22. CDC. Fact sheet: diagnosis of tuberculosis disease. www.cdc.gov/tb/publica tions/factsheets/testing/diagnosis.htm. Accessed November 12, 2014.

23. Pai M, Zwerling A, Menzies D. Systematic review: T-cell–based assays for the diagnosis of latent TB infection: an update. Ann Intern Med. 2008;149(3): 177-184.

24. LoBue PA, Castro KG. Is it time to replace the tuberculin skin test with a blood test? JAMA. 2012;308(3):241-242.

25. Mancuso JD, Mazurek GH, Tribble D, et al. Discordance among commercially available diagnostics for latent TB infection. Am J Respir Crit Care Med. 2012;185(4):427-434.

26. Wrighton-Smith P, Sneed L, Humphrey F, et al. Screening health care workers with interferon-γ release assay versus tuberculin skin test: impact on costs and adherence to testing (the SWITCH study). J Occup Environ Med. 2012;54(7):806-815.

27. World Health Organization. Use of tuberculosis interferon-gamma release assays (IGRAs) in low- and middle-income countries. www.who.int/tb/
features_archive/policy_statement_igra_oct2011.pdf. Accessed November 12, 2014.

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