Breast Cancer
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Bernard Fisher at 95
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Long-term CCB therapy linked to higher breast cancer risk
Major finding: Long-term use of calcium-channel blockers (10 years or more) was related to increased risk of breast cancer, with an OR of 2.4 for...
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Age does not impact survival in HER2-positive breast cancer
Major finding: Among women with HER2 positive breast cancer, disease free survival (HR 1.18; 95% CI, 0.90-1.54) and overall survival (HR 1.01; 95...
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Guidelines issued on radiation-induced heart disease
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Stem cell mutations in breast cancer may confer metastatic risk
Major finding: Nine of 10 specimens with mutations in breast cancer stem and progenitor cells, as compared with 4 of 20 tumors without BCSC...
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Racial discrepancy in breast cancer survival examined
Major finding: When breast cancer patients were matched for demographic characteristics at presentation, 5-year survival was 68.8% for white women...
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Genetic alterations affect everolimus benefit in breast cancer
Major Finding: Everolimus decreased the risk of progression or death by 73% in patients whose tumors had none or one genetic alteration in the...
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Upamostat falls short in HER2-negative metastatic breast cancer
Major finding: Adding upamostat vs. placebo did not significantly prolong progression-free survival in the entire trial population (8.3 vs. 7.5...
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BOLERO 3: Everolimus may overcome trastuzumab resistance in HER2-positive breast cancer
Major finding: Compared with placebo, everolimus led to better progression-free survival when added to trastuzumab and vinorelbine (hazard ratio,...
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Do cosmetic breast implants hinder the detection of malignancy and reduce breast cancer–specific survival?
Yes. According to this systematic review and two meta-analyses of observational studies, cosmetic breast augmentation adversely affects survival...