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Abdominal aortic calcification may further raise known fracture risk
Men with a prevalent vertebral fracture on lateral spine radiograph had even greater risk for future osteoporotic fractures with increasing...
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Checkpoint inhibitors’ ‘big picture’ safety shown with preexisting autoimmune diseases
A Dutch nationwide study in melanoma patients found relative safety of immune checkpoint inhibitors for grade 3 immune-related AEs but does not...
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Tofacitinib for RA misses the mark in safety study
Pfizer announced primary outcome results for major adverse cardiovascular events and cancers in postmarketing ORAL Surveillance study.
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Treprostinil offers some benefits for patients with ILD-associated pulmonary hypertension
The INCREASE trial was multicenter, randomized, double blind, and placebo controlled.
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Ehlers-Danlos syndrome associated with various complications in hospitalized patients
“This study legitimizes what many who take care of patients with EDS know to be true, and for those who don’t, it brings a lot of attention to...
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Oral steroids plus PPIs increase osteoporotic fracture risk in RA patients
The risk of fracture in patients taking both drugs rose beyond what was seen in those taking either drug alone in this retrospective, population-...
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Slow taper off antimalarial is best to avoid lupus flare during remission
“Except in the setting of toxicity, cessation of antimalarial medication in patients with disease quiescence is feasible using a slow taper,” said...
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ASSET extension supports abatacept as treatment for diffuse cutaneous systemic sclerosis
“Exploratory outcome measures during the [6-month] open-label extension, including the composite ACR CRISS score,...
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Low IgA levels associated with increased infection risk in SLE patients
“This is the first dedicated study to examine the relationship between acquired low immunoglobulins and infection risk in adult patients with SLE...
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Upadacitinib more effective, less safe than abatacept for RA
“Rheumatologists will be looking hard at future data to assess whether improved treatment outcomes justify an increased risk of adverse events,”...
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Experts assess infection risks for patients on biologics
Different DMARDs “all have fairly similar risks when it comes to ‘classical’ or routine bacterial infections. But when you talk about...
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Late-onset neutropenia more common than expected in patients on rituximab
“Even though most [cases] are incidental and can be self-limiting, some can be severe and associated with sepsis.”
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Smoking increases risk of high plasma NfL levels in patients with MS
Patients who have stopped smoking have notably lower risk that correlates to how long ago they quit.
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Lowering rituximab dose in patients with MS proves safe and effective
Among study participants, no relapses occurred in the year after lowering rituximab dosage to 500 mg.
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Blood biomarkers could help predict when athletes recover from concussions
Study results highlight the potential role of biomarkers in tracking neuronal recovery following sports-related concussion.