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Methotrexate-induced pulmonary fibrosis risk examined in 10-year study
LIVERPOOL, ENGLAND – There is no evidence that pulmonary fibrosis is a complication of long-term methotrexate use and treatment should continue...
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TissueGene-C effects on knee OA seen at 3 years
LIVERPOOL, ENGLAND – The novel intra-articular therapy improved multiple outcomes including knee pain, with a trend towards reversing structural...
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Heart disease in GPA exacts high toll in year 2 and beyond
LIVERPOOL, ENGLAND - Heart disease accounts for most granulomatosis with polyangiitis deaths 1-5 years after diagnosis.
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Aim for remission, not low disease activity, in rheumatoid arthritis
LIVERPOOL, ENGLAND – Remission brings better quality of life compared with low disease activity.
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Wearing lateral wedge insoles reduces osteoarthritis knee pain
LIVERPOOL, ENGLAND – Lateral wedge insoles were an effective means of reducing painful medial knee osteoarthritis in prescreened patients.
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Cathepsin K inhibitor exhibits bone protecting effects in osteoarthritis
LIVERPOOL, ENGLAND – The 6-month trial showed no reduction in pain versus placebo on an 11-point numerical rating scale.
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Patient-reported outcomes show impairment decades after acute knee injury
Knee pain, reduced quality of life, and osteoarthritis occur more than 30 years after ACL rupture.
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Targeting inactivity, mood, and cognition could be key to reducing OA mortality
LIVERPOOL, ENGLAND – OA was associated with a 15% increased risk of mortality in the general population.
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Siponimod trial ‘first’ to show delayed disability in secondary progressive MS
But the absolute difference in the rate of confirmed disability progression versus placebo was small.
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Accelerated breast irradiation advocated by ASTRO guideline
Expanded patient population eligible for whole breast hypofractionated radiation therapy in updated ASTRO guideline.
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Real-world data support extended cervical cancer screening interval
The study examines several rounds of cotesting with the high-risk HPV test and cytology.
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CV outcomes better with SGLT2 inhibitor than DPP4 inhibitor in T2DM study
In the real world, an SGLT2 inhibitor may protect against heart disease better that a DPP-4 inhibitor.
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Care needed using sotagliflozin as add-on to insulin in T1DM
LISBON – Handle with care: sotagliflozin imposes risk of DKA while dropping HbA1c.
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SGLT inhibition back on track in phase 3 type T1DM trial
LISBON – Sodium-glucose cotransporter inhibitors appear to be back on track for adjunctive use in people with T1DM.
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British Society of Rheumatology issues first U.K. lupus guideline
The guidelines are the first from any medical society for systemic lupus erythematosus overall since 2008.