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Promising first results with DNA editing to lower LDL
The first in-human HEART-1 trial of in vivo DNA editing called VERVE-101, shows reductions in LDL and PCSK9 protein in patients with familial...
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AI-ECG gets STEMI patients to cath lab sooner
An artificial intelligence electrocardiography app cut catheterization lab activation times by 9 minutes in ST-elevation myocardial infarction...
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GLP-1s don’t appear to worsen diabetic retinopathy
The findings do not obviate the need for providers to have a conversation about the potential risks to vision posed by the drug.
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Trial shows utility of small-volume blood collection tubes
A clinical trial in Canada has found that small-volume blood collection tubes equal standard-volume tubes for specimen capture while reducing...
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Dropping aspirin cuts bleeding in LVAD patients: ARIES-HM3
“We’ve always thought that somehow aspirin prevents stroke and prevents clotting and that it’s anti-inflammatory, and what we found in ARIES was...
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Potential dapagliflozin benefit post MI is not a ‘mandate’
“From my perspective, DAPA-MI does not suggest a new mandate to expand SGLT2 inhibition to an isolated MI population without other SGLT2 inhibitor...
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IPF pipeline crowded with new drug candidates
Almost 90 clinical trials are evaluating drugs to that target unmet needs for treating idiopathic pulmonary fibrosis.
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Residential move after a heart attack raises mortality risk
“Clinicians need better awareness that the need to change residence is an important marker of changing health status and may portend end-of-life...
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Few meet eligibility for newer Alzheimer’s drugs
Fewer than 10% of early Alzheimer’s patients in a real-world cohort would qualify for trials of anti–amyloid-beta monoclonal antibodies, a study...
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AI in pulmonary medicine – imaging and beyond
Emerging artificial intelligence tools in pulmonology are crunching electronic records and physiological signals to improve predictive models.
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Concussion may not affect IQ in children
“The message I give parents is that most kids recover within 2-4 weeks.”
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Same-session PCI rates ‘surprisingly high’
In a large database, more than three-quarters of stable patients had percutaneous coronary intervention with the index catheterization,...
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Does colchicine have a role in treating excess ASCVD risk in patients with chronic inflammatory conditions?
Experts in rheumatology, dermatology, and gastroenterology assess the potential of colchicine 0.5 mg to treat residual risk for atherosclerotic...
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Ticagrelor, DAPT equal in preventing repeat revascularization
After percutaneous coronary intervention, ticagrelor alone or with aspirin are equally effective in preventing repeat revascularization at 1 year...
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Real-world data validate ESC risk model in NSTE-ACS
A real-world study has potentially validated a risk model put forward by the ESC for management of acute coronary syndromes without persistent ST-...