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    Mitchel L. Zoler, PhD

    Mitchel is a reporter for MDedge based in the Philadelphia area. He started with the company in 1992, when it was International Medical News Group (IMNG), and has since covered a range of medical specialties. Mitchel trained as a virologist at Roswell Park Memorial Institute in Buffalo, and then worked briefly as a researcher at Boston Children's Hospital before pivoting to journalism as a AAAS Mass Media Fellow in 1980. His first reporting job was with Science Digest magazine, and from the mid-1980s to early-1990s he was a reporter with Medical World News. @mitchelzoler

    News

    ‘Stunning’ twincretin beats semaglutide for A1c, weight reduction in T2D

    Author:
    Mitchel L. Zoler, PhD
    Publish date: June 26, 2021

    Head-to-head pivotal trial results show weekly tirzepatide injections surpassed 1 mg semaglutide weekly for A1c reduction and weight loss.

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    News

    Medically suspect criterion can determine bariatric surgery coverage

    Author:
    Mitchel L. Zoler, PhD
    Publish date: June 18, 2021

    Some health insurers require certain patients seeking bariatric surgery to first-fail treatment with three...

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    News

    Bariatric surgery cuts insulin needs in type 1 diabetes with severe obesity

    Author:
    Mitchel L. Zoler, PhD
    Publish date: June 17, 2021

    By substantially cutting weight and thereby boosting insulin sensitivity bariatric surgery helps patients with...

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    News

    Bariatric surgery tied to fewer HFpEF hospitalizations

    Author:
    Mitchel L. Zoler, PhD
    Publish date: June 15, 2021

    Data from the U.S. National Inpatient Sample show a significant link between prior bariatric surgery and fewer...

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    News

    ‘Twincretin’ meets primary endpoints in five pivotal diabetes trials

    Author:
    Mitchel L. Zoler, PhD
    Publish date: June 14, 2021

    Lilly’s novel “twincretin” tirzepatide met its primary, A1c-lowering endpoint in five pivotal RCTs of patients...

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    News

    Mavacamten boosts quality of life in patients with hypertrophic cardiomyopathy

    Author:
    Mitchel L. Zoler, PhD
    Publish date: June 4, 2021

    Oral mavacamten significantly improved quality of life in a prespecified secondary endpoint from the EXPLORER-HCM pivotal trial.

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    News

    Dapagliflozin’s cost-effectiveness ‘intermediate’ for HFrEF

    Author:
    Mitchel L. Zoler, PhD
    Publish date: June 3, 2021

    Results from DAPA-HF and U.S. pricing show dapagliflozin costs about $84,000/quality-adjusted life year, which...

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    News

    Prediabetes linked to higher CVD and CKD rates

    Author:
    Mitchel L. Zoler, PhD
    Publish date: June 2, 2021

    Data from more than 330,000 U.K. adults show that an A1c of 5.7%-6.4% links with higher rates of incident CKD and CVD events.

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    News

    Rivaroxaban cut recurrent limb events in VOYAGER-PAD

    Author:
    Mitchel L. Zoler, PhD
    Publish date: May 26, 2021

    Analysis of both first and subsequent major adverse limb events in the VOYAGER-PAD trial documents ongoing...

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    News

    Sotagliflozin’s HFpEF benefit confirmed by new analyses

    Author:
    Mitchel L. Zoler, PhD
    Publish date: May 24, 2021

    A meta-analysis of two pivotal trials for the SGLT1/2 inhibitor sotagliflozin prospectively documents a HFpEF...

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    News

    FIDELIO-DKD: Finerenone cuts new-onset AFib in patients with type 2 diabetes and CKD

    Author:
    Mitchel L. Zoler, PhD
    Publish date: May 18, 2021

    A prespecified, exploratory analysis from the FIDELIO-DKD trial showed that the nonsteroidal MRA finerenone...

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    News

    Ultrasound renal denervation drops BP in patients on triple therapy

    Author:
    Mitchel L. Zoler, PhD
    Publish date: May 16, 2021

    In a sham-controlled, randomized study, renal denervation with ultrasound cut systolic blood pressure by a...

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    News

    PARADISE-MI: Sacubitril/valsartan can’t beat ramipril in patients with acute MI

    Author:
    Mitchel L. Zoler, PhD
    Publish date: May 15, 2021

    When treating patients with no history of heart failure within days of an acute myocardial infarction,...

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    News

    FDA blazes path for ‘real-world’ evidence as proof of efficacy

    Author:
    Mitchel L. Zoler, PhD
    Publish date: May 11, 2021

    FDA leaders must finalize guidance this year on submitting real-world observational evidence for regulatory decisions on drug and device efficacy...

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    News

    Finerenone scores second pivotal-trial success in patients with diabetic kidney disease

    Author:
    Mitchel L. Zoler, PhD
    Publish date: May 10, 2021

    Top-line results from FIGARO-DKD, the second pivotal trial for finerenone in patients with type 2 diabetes and...

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