News

Anticipated Effects of Pneumococcal Vaccines on Otitis
- Author:
- Michael E. Pichichero, MD
As we commence use of PCV15 and PCV20 in the United States, our data provide insights regarding estimation of the projected effects of these...
News

Predicting and Understanding Vaccine Response Determinants
- Author:
- Michael E. Pichichero, MD
Cytokines measured in nasopharyngeal secretions in the neonatal period may predict vaccine response.
News

Microbiome Impacts Vaccine Responses
- Author:
- Michael E. Pichichero, MD
A major factor affecting immune development is the microbiome of the newborn and the first 100 days of life.
News

Laissez-faire
- Author:
- Michael E. Pichichero, MD
While reducing antibiotic resistance is an important concern at a patient and community level, we should not become complacent about the risks to...
News

Profile of respiratory bacteria in children younger than 6 months
- Author:
- Michael E. Pichichero, MD
Researchers provide heretofore unreported contemporary data in a highly PCV13-immunized, community-based child population in the United States.
Opinion

Young children quickly outgrow the need for ear tubes
- Author:
- Michael E. Pichichero, MD
Children having several ear infections in a short time does not predict that they will have a similar number of ear infections in the future.
Opinion

Immunity debt and the tripledemic
- Author:
- Michael E. Pichichero, MD
The significant reduction in respiratory illness during the COVID-19 epidemic we and others observed resulted in a large pool of children who did...
Opinion

Acute otitis media pneumococcal disease burden in children due to serotypes not included in vaccines
- Author:
- Michael E. Pichichero, MD
In pneumococcal conjugate–vaccinated populations, vaccine pressure and antibiotic resistance drive PCV serotype replacement with nonvaccine...
Opinion

Antibiotics use and vaccine antibody levels
- Author:
- Michael E. Pichichero, MD
Our study adds new reasons to be cautious about overprescribing antibiotics on an individual child basis because an adverse effect extends to...
Opinion

Effect of COVID-19 pandemic on respiratory infectious diseases in primary care practice
- Author:
- Michael E. Pichichero, MD
- Steven A. Schulz, MD
Public health measures to prevent the spread of SARS-CoV-2 included a concurrent reduction in risk for children to acquire and spread respiratory...
Opinion

Respiratory infection– and asthma-prone children
- Author:
- Michael E. Pichichero, MD
The pathogenesis, development, severity, and clinical outcomes of respiratory infections are largely dependent on the resident composition of the...
Opinion

Myth busting: SARS-CoV-2 vaccine
- Author:
- Michael E. Pichichero, MD
The mRNA and replication-defective DNA vaccines never interact with your DNA. They cannot alter your DNA.
Opinion

Understanding messenger RNA and other SARS-CoV-2 vaccines
- Author:
- Michael E. Pichichero, MD
Technological advances make these new and revolutionary vaccines a reality.
Opinion

COVID-19: A primary care perspective
- Author:
- Steven A. Schulz, MD
- Michael E. Pichichero, MD
Continued education, cooperation, and adaptation will be needed in the months ahead.
Opinion

Why is AOM frequency decreasing in the pneumococcal conjugate vaccine era?
- Author:
- Michael E. Pichichero, MD
Changing recommendations and campaigns to reduce unnecessary and inappropriate antibiotic use appear to be some...