News

Small study suggests natural HCV clearance is caused by AR3-antibody response
- Author:
- Mark S. Lesney
Cross-genotype and neutralizing antibodies, especially targeting AR3, contribute to HCV clearance and long-term protection.
News

Ebola outbreak: WHO/OCHA call for more aid, better security
- Author:
- Mark S. Lesney
Security, public trust, and a lack of resources are significant barriers to countering the current Ebola epidemic in the Democratic Republic of...
News

Patients with COPD at heightened risk for community-acquired pneumonia requiring hospitalization
- Author:
- Mark S. Lesney
COPD patients were about 18 times more likely to develop community-acquired pneumonia requiring hospitalization.
News

Microvascular disease: An independent and exacerbating risk factor for amputation
- Author:
- Mark S. Lesney
The presence of microvascular disease plus peripheral artery disease resulted in a more than 20-fold increased risk of amputation than MVD or PAD...
News

FDA panel: Continue using paclitaxel-eluting PAD devices, with caveats
- Author:
- Mark S. Lesney
Although the benefits of the devices were clear, the panel felt there should be a label change to warn of the late mortality signal seen in a key...
Article

FDA panel to reassess the fate of paclitaxel-coated PAD devices
- Author:
- Mark S. Lesney
The FDA is requesting the panel’s input regarding the presence and magnitude of the increased mortality signal and its potential causes.
News

Despite HCV cure, liver cancer-associated genetic changes persist
- Author:
- Mark S. Lesney
Liver tissue from HCV-infected with and without sustained virologic response found epigenetic and gene...
News
Respiratory effects may account for worse survival in women undergoing DTA and TAAA repair
- Author:
- Mark S. Lesney
Women had significantly worse 5-year survival than men undergoing DTA or TAAA repair (59.7% vs. 66.2%, P...
News

DOPPS participation associated with lower HCV rates in dialysis patients
- Author:
- Mark S. Lesney
HCV infection decreased from 2.9 to 1.2 per 100 patient-years in countries participating in the initial phase of DOPPS.
News

Higher serum leptin levels associated with PAD
- Author:
- Mark S. Lesney
Serum leptin levels are positively and independently associated with PAD.
News

New vascular 0 + 5 training programs yield fewer PAD cases
- Author:
- Mark S. Lesney
VSFs currently perform more endovascular and open cases than their 0 + 5 IVSR counterparts for peripheral...
News
Ask patients, not devices, about impact of PAD
- Author:
- Mark S. Lesney
Direct assessment from patients is the best measure of the impact of PAD on patients’ symptoms, functional...
News

HCC linked to mitochondrial damage, iron accumulation from HCV
- Author:
- Mark S. Lesney
Mitochondrial damage and iron accumulation from HCV are linked to the development of hepatocellular carcinoma.
News

Patient complications affect surgeons adversely
- Author:
- Mark S. Lesney
Patient complications affect surgeons’ emotional health, and organizations must acknowledge this and develop...
News

An HCV-infected population showed gaps in HBV testing, vaccination, and care
- Author:
- Mark S. Lesney
A cohort of HCV-infected patients showed a high prevalence of current or past HBV infection, but with gaps in...