M. Alexander Otto began his reporting career early in 1999 covering the pharmaceutical industry for a national pharmacists' magazine and freelancing for the Washington Post and other newspapers. He then joined BNA, now part of Bloomberg News, covering health law and the protection of people and animals in medical research. Alex next worked for the McClatchy Company. Based on his work, Alex won a year-long Knight Science Journalism Fellowship to MIT in 2008-2009. He joined the company shortly thereafter. Alex has a newspaper journalism degree from Syracuse (N.Y.) University and a master's degree in medical science -- a physician assistant degree -- from George Washington University. Alex is based in Seattle.
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Drug conjugate extends life in HER2+ end-stage metastatic colorectal cancer
- Author:
- M. Alexander Otto
An almost 50% response rate is “very exciting.”
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Study findings support consideration of second biopsy for transected melanomas
- Author:
- M. Alexander Otto
Accurate Breslow depth is necessary for surgical decisions.
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Mohs surgery favorable as monotherapy for early Merkel cell carcinomas
- Author:
- M. Alexander Otto
Small series adds to growing body of literature.
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Checkpoint inhibitors earn spot in new ESMO SCLC guidelines
- Author:
- M. Alexander Otto
ESMO calls for upfront atezolizumab or durvalumab with etoposide and a platinum for stage 4 SCLC.
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Study supports intensifying chemoradiotherapy for head and neck cancer
- Author:
- M. Alexander Otto
Intensifying chemoradiotherapy appeared to improve outcomes in locally advanced head and neck cancer.
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Novel hedgehog inhibitor strategies improve BCC outcomes
- Author:
- M. Alexander Otto
Upfront tumor debulking seems to help.
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Checkpoint inhibitor skin side effects more common in women
- Author:
- M. Alexander Otto
"Clinicians should consider these results in counseling female patients regarding an elevated risk of dermatologic adverse events."
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Lobaplatin deemed ‘promising alternative’ to cisplatin in nasopharyngeal carcinoma
- Author:
- M. Alexander Otto
A lobaplatin-based regimen was as effective as a cisplatin-based regimen in a phase 3 trial.
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Survival benefit with nivolumab extends to 5 years in NSCLC
- Author:
- M. Alexander Otto
Early response portends durable outcome, but the optimal duration of treatment is uncertain.
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Cell-free DNA improves response prediction in breast cancer
- Author:
- M. Alexander Otto
Using cell-free DNA and MRI in combination improved prediction of pathological complete response.
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Adverse reactions to immunotherapy can appear after a year
- Author:
- M. Alexander Otto
Some melanoma patients receiving anti-PD-1 immunotherapy may tolerate the drug well for months but then develop...
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Combo provides ‘broad benefit’ across NHL subtypes
- Author:
- M. Alexander Otto
Adding copanlisib to rituximab improved progression-free survival, but overall survival data are not mature.
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Endometrial thickness could predict cancer, guide lymph node assessment
- Author:
- M. Alexander Otto
Patients with endometrial intraepithelial neoplasia don’t need routine lymph node sampling, an investigator says.
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Negative results when immunotherapy was added to chemoradiotherapy
- Author:
- M. Alexander Otto
A phase 3 trial investigating the addition of avelumab to chemoradiotherapy in patients with head and neck cancer was stopped early.
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Technique combines ‘best of both worlds’ to target lung nodules
- Author:
- M. Alexander Otto
Bronchoscopic transbronchial microwave ablation proved feasible in a small study.