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Osimertinib plus chemo ups PFS, toxicity in first line
Combining osimertinib with chemotherapy improved progression-free survival in EGFR-mutated non–small cell lung cancer, new interim data show, but...
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Novel ADC offers hope in heavily pretreated NSCLC
A phase 2 trial found that almost 30% of patients receiving antibody-drug conjugate patritumab deruxtecan achieved an objective response, and...
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Probing the link between GERD and anxiety and depression
An analysis suggested that a genetic risk for GERD increased the risk of developing depression or anxiety and vice versa.
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Unlocking the secrets of brown fat
Since obesity results from an imbalance between energy intake and energy expenditure, one model proposes that brown adipocytes rebalance this...
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Probiotics improve nonmotor symptoms of Parkinson’s
Participants taking the probiotic also saw a reduced delay in “time to on” of treatment with levodopa, thus reducing the delay until effectiveness...
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Even an hour’s walk a week lowers risk in type 2 diabetes
“Our findings are particularly promising for neuropathy since, currently, no disease-modifying treatment exists, and there are limited preventive...
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Both too much and not enough sleep raises T2D risk
“These findings underpin the importance of promoting healthy sleep habits to avoid sleep deprivation.”
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Simple blood test may predict heart and kidney risk in T2D
“Three out of the four biomarkers are already clinically and commercially available,” while the fourth, for insulin-like growth factor binding...
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New guide for acute liver failure urges early treatment, transplant referral
The clinical guidelines focus on the diagnosis and management of patients with acute liver failure.
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Two-pronged approach needed in alcohol-associated hepatitis
Patients are likely to carry a dual diagnosis of liver disease and alcohol use disorder.
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Anticoagulants for cancer-related VTE: What works best?
These data may “help facilitate shared decision-marking and inform clinical guidelines for the treatment of such patients.”
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Retinal thickness a new predictor of MS disability?
The imaging technique cannot be used for all patients and is currently not widely available.
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Gene therapy promising for reversal of hereditary vision loss
The results confirm in a “real-life setting” the efficacy and safety of the treatment.
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Higher risk of death with endocrine therapy nonadherence
“Importantly, improving adherence and persistence represents a low-hanging fruit for increasing survival in luminal breast cancer.”
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Global burden of brain disorders surpasses cardiovascular disease and cancer
“The burden of brain conditions will increase as populations continue to grow and age.”