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Hormonal contraceptives protective against suicide?
The main message is the “current use of hormonal contraceptives is not associated with an increased risk of attempted suicide in our population...
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Post-hoc analysis offers hope for novel cholesterol drug
A second look at vupanorsen revealed its effects on VLDL and remnant cholesterol levels in TRANSLATE-TIMI 70, which had disappointing primary...
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Genetic testing for best antidepressant accurate, cost effective
Had psychiatrists who treated patients in the study known about their metabolizing profiles, it “might have contributed to switches in medication...
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In utero COVID exposure tied to developmental differences in infants
“We don’t know if these effects will result in any longer-term issues,” but longer-term observation “may help us understand this.”
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Panitumumab beats bevacizumab in left-sided mCRC
In the U.S., the choice between an anti-EGFR or anti-VEGF antibody for colorectal cancer has been controversial.
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Improved survival in subset of advanced pancreatic cancer
A new drug under study for patients with pancreatic cancer targets EGFR leading to one-year survival rates of 43.6% for patients.
Article
'New benchmark' set in phase-3 blood cancer study
Phase 3 SHINE study of older patients with mantle cell lymphoma yields “profound” results with ibrutinib add-on.
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LDL lowering to specific targets may offset risk from high Lp(a)
Researchers have developed a novel app to show how the increased risk of coronary events due to elevated lipoprotein(a) levels can be countered by...
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PPIs should be used ‘judiciously’ in patients with cirrhosis
“Experts call for “nuanced” prescribing of proton pump inhibitors to patients with cirrhosis in study that found lower mortality only in those...
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Misconceptions remain on gene signature use in breast cancer
The “misconception regarding the predictive value of these tests on chemotherapy benefits suggest there is still room for training on results...
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High antipsychotic switch rates suggest ‘suboptimal’ prescribing for first-episode psychosis
Researchers found the most common first treatment switch, in 17.9% of patients, was from olanzapine to aripiprazole.
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New combination med for severe mental illness tied to less weight gain
Results of a 12-week study showed a significant difference in percent change in body weight from baseline between two treatment groups.
News
TNF inhibitors prior to surgery safe in patients with IBD: Study
The rate of postoperative infection is no different between patients exposed to and those unexposed to tumor necrosis factor inhibitors in the 12...
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Zanubrutinib shows worth against standard CLL drugs
New CLL drug demonostrates its efficacy in the crowded field of CLL treatment options.
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‘Fragmented’ speech patterns may predict psychosis relapse
New research suggests that “semantic speech networks can enable deeper phenotyping of formal thought disorder and psychosis.”