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Review may help clinicians treat adolescents with depression
“We did two systematic reviews to look at the continuing professional development of family physicians in adolescent health, and it turned out...
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Metronomic chemotherapy performs well in second-line head and neck cancer
Lower-dose therapy granted PFS and OS gains, with fewer side effects, compared with standard chemotherapy options.
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Antibody-drug conjugate changes standard of care for platinum-resistant ovarian cancer
A novel therapy has a favorable safety profile, and more like it may be on the way.
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SCLC: Bispecific antibody shows phase 1 promise
The antibody targets delta-like ligand 3, which is one of few surface markers for small cell lung cancer.
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Surgical de-escalation passes clinical test in low-risk cervical cancer
‘Practice-changing’ results could reduce long-term survivor effects among qualifying patients.
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Stem cell transplants are more effective than some MS therapies
The results of the new study are “encouraging,” but plenty of unanswered questions remain.
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Circulatory support for RV failure caused by pulmonary embolism
A new review highlights three mechanical circulatory support options in high-risk patients, but teamwork is key.
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Psyllium may shield against colitis
A mouse study suggests an effect on inflammation by boosting bile acid metabolism.
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PDAC surveillance in high-risk cases improves outcomes
A propensity-matched analysis found a benefit even after considering lead-time bias, suggesting a real benefit.
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AGA clinical practice update: Extraesophageal gastroesophageal reflux disease
Extraesophageal reflux symptoms are a subset of gastroesophageal reflux disease that can be difficult to diagnose.
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Guidelines for assessing cancer risk may need updating
Whole-exome sequencing reveals cancer risk mutations in patients that would not have qualified for testing based on current guidelines.
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AI predicts endometrial cancer recurrence
Model uses only digitized histopathology slides, but more validation in other populations is needed.
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PARP/ATR inhibitor combo shows hints of promise in children with tumors
A phase 1 clinical trial could provide biomarker clues to help guide future studies.
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Circulating DNA has promise for cancer detection, but faces challenges
Unnecessary procedures and health care challenges could leave Whites as the primary beneficiaries.
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Pembrolizumab monotherapy effective for rare melanoma
Patients with unresectable desmoplastic melanoma experienced a response rate that was nearly double other melanomas.