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Vaccines protect unborn mice from Zika infection
Researchers have reported that 2 different vaccines can protect mice from Zika virus-induced congenital disease. Female mice that were vaccinated...
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PD-1 inhibitors treat resistant gray zone lymphoma
Three case reports published in The New England Journal of Medicine describe the successful use of PD-1 inhibitors in gray zone lymphoma. Two...
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Gene therapy maintains normal FVIII levels long-term
BERLIN—New research suggests the investigational gene therapy BMN 270 can allow patients with severe hemophilia A to maintain normal factor VIII (...
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De-escalation may improve success of TKI cessation
MADRID—Results of the DESTINY trial suggest that chronic myeloid leukemia (CML) patients may improve their chances of successfully stopping...
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Blinatumomab granted full approval to treat rel/ref BCP-ALL
The US Food and Drug Administration (FDA) has approved the supplemental biologics license application (sBLA) for blinatumomab (Blincyto®). The...
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ODAC recommends approval of CTL019 in rel/ref ALL
The US Food and Drug Administration’s (FDA) Oncologic Drugs Advisory Committee (ODAC) has unanimously recommended approval for the chimeric...
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Benefits of gemtuzumab ozogamicin outweigh risks, ODAC says
The US Food and Drug Administration’s (FDA) Oncologic Drug Advisory Committee (ODAC) has announced a positive opinion of gemtuzumab ozogamicin (GO...
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Idarucizumab reverses effects of dabigatran in emergencies
BERLIN—Final results from the RE-VERSE AD trial suggest idarucizumab can reverse the anticoagulant effect of dabigatran etexilate mesylate in...
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FDA grants priority review to sNDA for dasatinib
The US Food and Drug Administration (FDA) has accepted for priority review a supplemental new drug application (sNDA) for dasatinib (Sprycel)....
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Company launches automated hematology analyzers in US
Sysmex America, Inc.
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Antibody reduces bleeding in hemophilia A patients with inhibitors
BERLIN—Emicizumab can reduce bleeding in adults and adolescents with hemophilia A and inhibitors to factor VIII, according to a phase 3 trial. In...
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Vaccine granted orphan designation for MDS
The US Food and Drug Administration (FDA) has granted orphan drug designation to DSP-7888, an investigational cancer peptide vaccine, for the...
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Antibody could reduce bone fractures in MM
Preclinical research suggests a targeted therapy may be able to rebuild and strengthen bone in patients with multiple myeloma (MM). Researchers...
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Common insurance plans exclude NCI, NCCN cancer centers
Narrow insurance plan coverage may prevent US cancer patients from receiving care at “high-quality” cancer centers, according to research...
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FDA approves new treatment for sickle cell disease
The US Food and Drug Administration (FDA) has granted approval for L-glutamine oral powder (Endari), the first treatment approved to treat sickle...