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How Abl ‘shape-shifts’ in drug-resistant CML
Researchers say they have determined how the structure of Abl kinase regulates its activity, enabling the enzyme to switch itself on and off. The...
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Fostamatinib elicits responses in AIHA
The oral SYK inhibitor fostamatinib can produce responses in patients with warm antibody autoimmune hemolytic anemia (AIHA), according to Rigel...
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Caplacizumab may enhance treatment of aTTP
Caplacizumab can improve upon standard care for patients with acquired thrombotic thrombocytopenic purpura (aTTP), according to results reported...
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Drug receives breakthrough designation for HL
The US Food and Drug Administration (FDA) has granted breakthrough therapy designation to brentuximab vedotin (BV, Adcetris) for use in...
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FDA grants EUA to Zika testing system
The US Food and Drug Administration (FDA) has granted emergency use authorization (EUA) for Chembio Diagnostics, Inc.’s DPP® Zika System. The...
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As cord blood inventory increases, use declines
Recently, the US has seen a decline in the use of cord blood in transplants, according to a study by the RAND Corporation. The research revealed...
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Doc advocates depression screening for cancer patients
SAN DIEGO—New research suggests a need for mental health screening among cancer patients. The study revealed a 40% rate of depression among...
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Japan approves product for hemophilia A
Japan’s Ministry of Health, Labor and Welfare has approved lonoctocog alfa (AFSTYLA®), a recombinant single-chain coagulation factor VIII product...
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Maintenance will be a new standard in MCL, doc says
Results of a phase 3 trial suggest rituximab maintenance after transplant can prolong survival in non-elderly patients with mantle cell lymphoma (...
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Drugs could improve treatment of CML
Preclinical research suggests 2 drugs already approved for use in the US may improve upon tyrosine kinase inhibitor (TKI) therapy in patients with...
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FDA improves public access to AE data
The US Food and Drug Administration (FDA) has launched a new search tool designed to improve access to data in the FDA’s Adverse Event Reporting...
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Older RBCs may sometimes be better
New research suggests that, overall, the age of transfused red blood cells (RBCs) does not significantly impact outcomes in critically ill adults...
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Daratumumab combos approved to treat MM in Japan
The Ministry of Health, Labor and Welfare in Japan has approved the use of daratumumab (DARZALEX®) in combination with lenalidomide and...
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FDA grants factor IX therapy orphan designation
The US Food and Drug Administration (FDA) has granted orphan drug designation to CB 2679d/ISU304, a clinical stage drug candidate for hemophilia B...
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Mutations impact outcomes in AML, MDS
Researchers say they have identified genetic mutations that can significantly affect treatment outcomes in patients with acute myeloid leukemia (...