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‘Essential’ genes could be targeted to treat malaria
More than 2000 genes are “essential” for the malaria parasite Plasmodium falciparum, according to research published in Science. Researchers...
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Study shows increased risk of VTE among earthquake evacuees
New research has revealed a link between earthquake evacuation and venous thromboembolism (VTE). The study showed that people who spent the night...
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Blood type linked to death risk after trauma
Having type O blood is associated with high death rates in severe trauma patients, according to a study published in Critical Care. Researchers...
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Single injection could treat hemophilia B long-term
Cell therapy could produce lasting effects in hemophilia B, according to a group of researchers. They genetically modified induced pluripotent...
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FDA issues CRL for proposed biosimilar rituximab
The US Food and Drug Administration (FDA) has issued a complete response letter (CRL) saying the agency cannot approve Sandoz’s proposed...
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JAK inhibitor reduces GVHD in mice
An investigational JAK1/2 inhibitor can fight graft-versus-host disease (GVHD), according to preclinical research published in Leukemia. The...
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FDA approves CAR T-cell therapy for lymphoma
The US Food and Drug Administration (FDA) has approved tisagenlecleucel (Kymriah®) for its second indication. The chimeric antigen receptor (CAR)...
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Drug may alleviate CIPN in MM patients
Researchers say they’ve discovered why multiple myeloma (MM) patients may experience chemotherapy-induced peripheral neuropathy (CIPN) when...
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PI3K inhibitors could treat HHT
Preclinical research suggests PI3K inhibitors could treat hereditary hemorrhagic telangiectasia (HHT). Experiments in mice and patient samples...
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Predicting response to CAR T-cell therapy in CLL
Researchers may have discovered why some patients with advanced chronic lymphocytic leukemia (CLL) don’t respond to chimeric antigen receptor (CAR...
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Team identifies 5 subtypes of DLBCL
New research has revealed 5 genetic subtypes of diffuse large B-cell lymphoma (DLBCL). Researchers identified a group of low-risk activated B-cell...
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Fostamatinib produces responses in ITP
Fostamatinib has produced “clinically meaningful” responses in adults with persistent or chronic immune thrombocytopenia (ITP), according to...
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CHMP backs approval of dasatinib for kids
The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended changes to the marketing authorization for...
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Drug receives breakthrough designation for HSCT-TMA
The US Food and Drug Administration (FDA) has granted a second breakthrough therapy designation to OMS721. OMS721 is a monoclonal antibody...
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CHMP recommends approval for generic carmustine
The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion of Carmustine Obvius, a...