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Doc laments increasing use of P values
Photo by Rhoda Baer A review of the biomedical literature indicates an increase in the use of P values in recent years, but researchers say this...
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Protein plays key role in B-ALL subtype
An RNA binding protein promotes the development of MLL-rearranged B-cell acute lymphoblastic leukemia (B-ALL), according to research published in...
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Idelalisib trials stopped due to AEs
Photo courtesy of Gilead Sciences The US Food and Drug Administration (FDA) has reported that Gilead Sciences, Inc., is stopping 6 clinical...
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Drug granted orphan designation for DLBCL
The US Food and Drug Administration (FDA) has granted orphan designation to the oncology drug candidate PNT2258 for the treatment of diffuse large...
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Intervention helps parents cope with kids’ HSCT
Photo by Chad McNeeley A new social-cognitive intervention can reduce stress in parents of children undergoing hematopoietic stem cell transplant...
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Gut microbes affect platelet function, thrombosis risk
Image by Andre E.X.
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Negative cancer trials have long-term impact
for a clinical trial Photo by Esther Dyson Cancer trials with negative results don’t make an immediate splash in the scientific literature, but...
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AEs prompt EMA review of idelalisib
Photo courtesy of Gilead Sciences, Inc. The European Medicines Agency (EMA) is reviewing the safety of idelalisib (Zydelig), a drug approved to...
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Class of drugs could treat B-cell malignancies
A class of drugs targeting a protein found in the endoplasmic reticulum could be effective against B-cell malignancies, according to a study...
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Allele associated with poor outcome in CLL
A form of the CYP3A7 gene is associated with poor outcomes in chronic lymphocytic leukemia (CLL) and other cancers, according to a study published...
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Product can reduce bleeding in hemophilia B
In a phase 3 study, prophylaxis with the recombinant factor IX product nonacog alfa (BeneFIX) reduced bleeding in patients with hemophilia B....
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Study elucidates MYC’s role in T-ALL
Image by Juha Klefstrom Research has revealed a relationship between the oncogene MYC and 2 cell-surface proteins that protect cancer cells from...
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Program can predict drug side effects
Photo by Darren Baker Scientists say they have developed a computer program that can predict whether or not a given pharmaceutical agent will...
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Regimen can reduce risk of malaria during pregnancy
Photo by Nina Matthews A 2-drug prophylactic regimen can reduce the risk of Plasmodium falciparum malaria during pregnancy, according to a study...
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Intracranial bleeding in older adults on warfarin
Results of a large study suggest warfarin may pose a higher risk of traumatic intracranial bleeding than previously reported, at least among older...