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Is low-dose naltrexone effective in chronic pain management?
EVIDENCE-BASED ANSWER: YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a...
Article
Does hormone replacement therapy prevent cognitive decline in postmenopausal women?
EVIDENCE-BASED REVIEW: NO. Hormone replacement therapy (HRT) does not prevent cognitive decline in postmenopausal women—and in fact, it may...
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Do behavioral interventions improve nighttime sleep in children < 1 year old?
EVIDENCE-BASED ANSWER: YES. Infants respond to behavioral interventions, although objective data are limited. Behavioral interventions include...
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Antibiotics and COPD: Time to order a C-reactive protein test?
Consider C-reactive protein–guided prescribing of antibiotics in acute chronic obstructive pulmonary disease exacerbations in the outpatient...
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Is NPH associated with fewer adverse events than analog basal insulin for adults with T2D?
EVIDENCE-BASED ANSWER: NO. Insulin glargine may lead to less patient-reported, symptomatic, and nocturnal hypoglycemia, although overall, there...
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Consider this Rx for patients with high triglycerides?
A daily dose of this prescription fish oil may be worth a trial in light of the cardiovascular benefits it affords statin-treated patients with...
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Do-it-yourself cervical cancer screening?
Enlisting patients to self-collect specimens for human papillomavirus testing is an effective way to detect cervical precancer in those who might...
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Immediate or delayed pushing in the second stage of labor?
Is there any advantage to delaying pushing in the second stage of labor for nulliparous women receiving epidural analgesia?
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Aspirin, Yes, for at-risk elderly—but what about the healthy elderly?
This study paints a decidedly different picture as to what role—if any—aspirin can play in the primary prevention of CVD for older adults.
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What is the best treatment for wrist ganglion cysts?
EVIDENCE-BASED ANSWER: Open surgical excision of wrist ganglion cysts is associated with a lower recurrence rate than aspiration with or without...
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Do Probiotics Reduce C diff Risk in Hospitalized Patients?
A systematic review and meta-analysis says, “Yes,” but that doesn’t necessarily mean they will start appearing on hospital...
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Should You Switch the DAPT Agent a Month After ACS?
A randomized controlled trial says “Yes,” but current guidelines say “No.”
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Do probiotics reduce C diff risk in hospitalized patients?
A systematic review and meta-analysis says, “Yes,” but that doesn’t necessarily mean they will start appearing on hospital formularies.
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How effective is spironolactone for treating resistant hypertension?
EVIDENCE-BASED ANSWER: Very effective. Spironolactone reduces systolic blood pressure (SBP) by 11 to 17 mm Hg and diastolic blood pressure (DBP)...
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Less Is More When It Comes to Ketorolac for Pain
It’s time to review our dosing with ketorolac for acute pain management.